Science

We are a world leader in NR and NAD research

The active ingredient in ChromaDex’s flagship consumer product TRU NIAGEN® is a unique and proprietary form of nicotinamide riboside ("NR") that safely and effectively increases nicotinamide adenine dinucleotide ("NAD") to support cellular health and resilience. The depth and consistency of the science supporting NR speaks to its value for promoting intrinsic capacity – the body’s ability to cope with physiologic stress.

What is NAD?

The molecule nicotinamide adenine dinucleotide (NAD) is constantly being consumed and created by cells to drive energy production and assist with cell defense and repair. Its levels have been shown to decline as we age. Reduced NAD levels are also associated with overnutrition, excessive alcohol consumption, sleep deprivation, sedentary lifestyle and several disease states. Its dwindling levels may be directly related to how we cope with these modern day stressors. Beyond declining with age, NAD is linked to resiliency because of the vital role it plays in both energy production, and the optimal function of our cells’ powerhouses (the mitochondria). More broadly, NAD supports a healthy cellular metabolism and repair processes. The molecule NAD helps practically every process by which cells break down food and build up and repair molecules like fats, DNA, and hormones.

What is NR?

Although researchers have known about nicotinamide riboside (NR) for decades, its full value as a nutrient wasn’t uncovered until 2004 when biochemist Dr. Charles Brenner and his team of researchers at Dartmouth discovered it could be a new form of vitamin B3, which serve as NAD precursors. While all of the vitamin B3s can be used by our cells to build new NAD molecules, Dr. Brenner and colleagues discovered that NR uses a specific pathway to convert NR into NAD, called the nicotinamide riboside kinase or NRK pathway.

Studies in cells and mice have shown that the NRK genes – which are necessary for converting NR into NAD – are activated by conditions of physiologic stress, including poor diet and viral infection, while other, more energy consuming NAD producing pathways from other B3s are suppressed. This research suggests that NR is cells’ preferred vitamin B3 when energy is low.

The first human clinical study of NR was published in 2016. The results demonstrated that NR was a safe and effective nutrient in people. Healthy aging, intrinsic capacity, mitochondria health and NAD have emerged as intense areas of focus in the research community.

Scientific Advisory Board

Science Highlights

10 Published Human
Clinical Studies

Multiple clinical trials demonstrate NIAGEN® is proven to safely and effectively boost NAD (nicotinamide adenine dinucleotide) levels, which decline with age.

100+ Preclinical
Studies

Preclinical studies at Dartmouth Medical School, University of Iowa, and École Polytechnique Fédérale de Lausanne lay the foundation for our human clinical trials.

3 FDA Safety
Notifications

NIAGEN® was twice successfully reviewed under FDA's new dietary ingredient (NDI) notification program, and also successfully notified to the FDA as generally recognized as safe (GRAS).

20+ Owned &
Licensed Patents

ChromaDex, holds a robust portfolio of domestic and international patents for both the production and distribution of NIAGEN®.

200+ Research
Collaborations

ChromaDex scientists partner with leading universities and research institutions worldwide to uncover the full potential of NAD and identify and develop novel, science-based ingredients.

Ongoing studies and publications

Notable Scientific Research - Preclinical

Download item year list
Date Download Description